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KMID : 0363320000210030389
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Journal of Korean Oriental Internal Medicine
2000 Volume.21 No. 3 p.389 ~ p.398
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Effects of Cordyceps militalis on the penile nitric oxide synthase activity and the level of blood testosterone in hydrocortisone acetate-treated rats
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Min Gun-Woo
Park Jong-Hyuk
Yoon Cheol-Ho
Jung Ji-Chun
Shin Uk-Seob
Han Young-Hwan
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Abstract
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The fallowing are the results of the experimental studies of Cordyceps militaris (CM) on the penile nitric oxide synthase (NOS) activity and the level of blood testosterone in hydrocortisone acetate-treated rats. CM was tested for the effects on activity of xanthine oxidase and lipid peroxidation in penis of hydrocortisone acetate-treated rats. In vitro, CM didn’t effect the levels of lipid peroxide and the activity of NOS. In the penis of hydrocortisone acetate-treated rats, lipid peroxide, the activities and ratio of type conversion of xanthine oxidase were increased but activity of NOS and content of nitrite were decreased. In vivo, after administration of CM to hydrocortisone acetate-treated rats, levels of lipid peroxide in penis was decreased. Also, the activities and ratio of type conversion of xanthine oxidase were decreased, too. The body weight and concentration of testosterone in the blood were increased. The effects of Cordyceps militalis Broth did better than the effects of Cordyceps militalls Mycelia,
These results suggest that CM decrease the activities of free radical generating enzymes such as xanthine oxidase which form lipid peroxide and increase the penile NOS activity and the level of blood testosterone in hydrocortisone acetate-treated rats. Conclusively, CM is capable of improving of sexual ability in hydrocortisone acetate-treated rats.
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KEYWORD
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Cordyceps militaris, hydrocortisone, nitrite, lipid peroxidation, testosterone
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